Legally Reviewed
This article has been written and reviewed for legal accuracy and clarity by Tort Defenders’ writers and staff and is as accurate as possible. This content should not be taken as legal advice from an attorney.
Non-Hodgkin’s lymphoma (NHL) is a type of cancer that originates in the lymphatic system, which is part of the body’s immune system. NHL can affect various organs and tissues, and it is characterized by the abnormal growth of lymphocytes, a type of white blood cell. While the exact cause of NHL remains unclear, there are several factors that can increase a person’s risk of developing this disease. Below, we explore the top 5 causes and risk factors of non-Hodgkin’s lymphoma.
Weakened Immune System
One of the most significant risk factors for developing non-Hodgkin’s lymphoma is having a weakened immune system. The immune system is responsible for identifying and attacking abnormal or cancerous cells. When the immune system is compromised, it may fail to detect and destroy these abnormal cells, allowing lymphoma to develop. Conditions that weaken the immune system include:
- HIV/AIDS: The human immunodeficiency virus (HIV) attacks the body’s immune cells, leaving individuals more vulnerable to infections and cancers, including NHL;
- Organ Transplants: People who receive organ transplants are often prescribed immunosuppressive medications to prevent organ rejection. These medications suppress the immune system, making it easier for cancer cells to grow unchecked;
- Autoimmune Diseases: Conditions like rheumatoid arthritis, lupus, and celiac disease are associated with an increased risk of NHL. In these diseases, the immune system attacks the body’s tissues, which may inadvertently contribute to the development of cancer.
Research has consistently shown that people with weakened immune systems are at a higher risk of NHL due to the body’s decreased ability to fight off abnormal cell growth. As immune system disorders become more prevalent, particularly with the rise of autoimmune diseases and organ transplants, the connection between immune system weakness and NHL remains an important area of study.
Age and Gender
The risk of developing non-Hodgkin’s lymphoma increases with age. NHL is more commonly diagnosed in individuals over the age of 60, though it can occur in younger individuals as well. The likelihood of being diagnosed with NHL continues to rise as people age, and this increase is particularly noticeable among individuals over 65.
In addition to age, gender also plays a role in the risk of developing NHL. Men are more likely to develop non-Hodgkin’s lymphoma than women. Researchers believe this disparity may be linked to hormonal differences, as well as genetic and environmental factors that affect men more than women.
While age and gender cannot be controlled, understanding that these are risk factors can help individuals take proactive steps in monitoring their health as they age, especially if they are at higher risk due to other factors.
Environmental Exposures
One of the most concerning risk factors for non-Hodgkin’s lymphoma is exposure to certain environmental factors, especially toxic chemicals. Pesticides, herbicides, and industrial chemicals have been identified as potential contributors to the development of NHL. Exposure to these substances, particularly over long periods of time, has been associated with increased cancer risk.
Glyphosate and Roundup
Glyphosate, the active ingredient in the popular herbicide Roundup, has come under significant scrutiny in recent years due to its potential link to non-Hodgkin’s lymphoma. The International Agency for Research on Cancer (IARC), part of the World Health Organization (WHO), classified glyphosate as a “probable human carcinogen” in 2015, particularly concerning its connection to NHL. This classification has sparked widespread debate and legal actions, with numerous studies suggesting that long-term exposure to glyphosate may increase the risk of developing non-Hodgkin’s lymphoma by causing damage to DNA and disrupting the immune system.
Many individuals have filed lawsuits against Monsanto (the maker of Roundup) after being diagnosed with non-Hodgkin’s lymphoma, alleging that their exposure to glyphosate during regular use of the herbicide led to the disease. If you or a loved one has been diagnosed with non-Hodgkin’s lymphoma and suspect glyphosate exposure, you may be eligible for compensation. Filing a legal claim with the help of an experienced attorney can help you seek justice for the harm caused by these toxic chemicals.
Glyphosate is widely used in agriculture and residential settings, making it an especially concerning risk factor for those exposed to it regularly. Despite the ongoing controversy surrounding glyphosate’s safety, it is essential to be aware of its potential dangers and to explore safer, chemical-free alternatives when managing weeds and pests in your garden or lawn.
Genetics and Family History
Genetic factors play a significant role in determining an individual’s risk of developing non-Hodgkin’s lymphoma. A family history of NHL or other types of cancer increases the likelihood of developing the disease. This may be due to inherited genetic mutations that predispose individuals to lymphoma or other cancers.
Certain inherited conditions can also increase the risk of NHL. For example, people with inherited immune system disorders or genetic mutations affecting the regulation of cell growth may be at a higher risk. Individuals with a family history of lymphoma or leukemia should be especially vigilant about monitoring their health and discussing their risk with their healthcare provider.
Though genetics cannot be changed, knowing your family history and discussing potential risks with your doctor can help with early detection and preventative care.
Infections
Infections have also been identified as significant contributors to the development of non-Hodgkin’s lymphoma. Certain viruses and bacteria can increase the risk of NHL, particularly in individuals with weakened immune systems. The most notable infections linked to NHL include:
- Epstein-Barr Virus (EBV): This common virus, which causes mononucleosis, has been strongly associated with several types of NHL. EBV can disrupt the immune system, allowing abnormal cell growth and increasing the risk of lymphoma;
- Human T-cell Leukemia Virus (HTLV-1): This virus is linked to a rare form of NHL known as adult T-cell leukemia/lymphoma;
- Helicobacter Pylori (H. pylori): This bacterium, which is commonly found in the stomach, has been linked to a specific type of NHL called gastric mucosa-associated lymphoid tissue (MALT) lymphoma.
These infections can lead to chronic inflammation and immune system changes that create an environment conducive to the development of cancer. While viral and bacterial infections are not direct causes of NHL, they can significantly increase the risk, particularly in individuals with compromised immune systems.
Protecting Yourself from NHL Risks
While the exact cause of non-Hodgkin’s lymphoma remains unclear, several key risk factors have been identified. A weakened immune system, age, gender, environmental exposures, genetics, and infections all contribute to an individual’s likelihood of developing NHL. Among these, environmental exposures, particularly to chemicals like glyphosate, have garnered significant attention due to their connection to the disease.If you or a loved one has been diagnosed with non-Hodgkin’s lymphoma and you suspect that exposure to glyphosate or other harmful chemicals may have contributed to the diagnosis, it’s important to seek legal counsel. You may be entitled to compensation for the harm caused by these toxic substances. An experienced attorney can help you navigate the legal process and seek justice for the impact that glyphosate exposure has had on your health.